Endocrine Abstracts

Interferon alfa-2a was discontinued in June 2020. Here we present a case of an unfortunate patient for whom this change has dramatically impacted the course of her illness. A 64-year-old woman initially presented in 2007 with refractory hypertension and was found to have a phaeochromocytoma which was resected. Metastatic recurrence of her disease in the liver and vertebrae was confirmed by CT/MRI in 2014 following rising catecholamines on monitoring. Her MIBG scan in early 201...

Background: Neuroendocrine tumours (NET) are heterogenous group of tumours commonly arising from Gastro-pancreatic (GI) and pulmonary origins. Combination of bowel resection, disease related diarrhoea and somatostatin analogue therapy (SSA) can contribute to vitamin B12 deficiency (B12D). International guidelines do not suggest routine screening. Total serum cobalamin (B12) level can be falsely normal in patients with B12D. Cells take up B12 in the form of Holotranscobalamin (...

Background: Everolimus, a mammalian target of rapamycin inhibitor, is licensed for use in adult pts with advanced well-differentiated pNETs in the UK. Limited Health-Related Quality-of-Life (HrQOL) data are available for everolimus therapy in these pts.Methods: This prospective study assessed changes in HrQoL (by monthly patient-reported EORTC QLQ-C30, -G.I.NET21 and EQ-5D questionnaires), in pts with pNETs during the first 6 months (mo) of treatment wit...